NIRvana InGaAs Camera Used in Ground-breaking NIR-II Fluorescence Imaging of Colorectal Cancer
December 5, 2019
Teledyne Princeton Instruments, a Teledyne Technologies [NYSE:TDY] company and world-renowned manufacturer of scientific imaging and spectroscopy equipment, is pleased to recognize the recently published work of a multidisciplinary research team in China and the USA. The collaboration has resulted in the design, construction, and characterization of an endoscopic system to perform targeted second near-infrared window (NIR-II) fluorescence imaging of colorectal cancer.†
The team used the new NIR-II endoscopy imaging system to evaluate a synthesized fluorescent molecular probe, indocyanine green (ICG) conjugated bevacizumab (Bev-ICG), which targets vascular endothelial growth factor (VEGF). The study, supported in part by the Natural Science Foundation of China, the Clinical Capability Construction Project for Liaoning Provincial Hospitals, and a China postdoctoral science foundation grant, was spearheaded by researchers at the Institute of Molecular Medicine Joint Laboratory for Molecular Medicine at Northeastern University in Shenyang, Liaoning.
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The study’s authors note that while endoscopy is a clinical gold standard for examining the interior of a hollow organ or body cavity, they are the first to report the use of NIR-II fluorescence endoscopy for the targeted detection of colorectal cancer. Their innovative endoscopic imaging system, which enables the simultaneous acquisition and display of white light and NIR-II fluorescence, delivers subcellular resolution of 20 μm for sharp images in the NIR-II region (i.e., 900 nm to 1700 nm).
Michael Melle, imaging product manager at Teledyne Princeton Instruments, says, “We are gratified to see the short-wavelength infrared (SWIR) sensitivity and quantitative capabilities of the NIRvana camera being leveraged for real-time, non-invasive imaging of colorectal tumor biomarkers.” Melle went on to say, “NIRvana technology offers a versatile, high-performance solution for myriad in vitro, ex vivo, and in vivo NIR-II fluorescence imaging applications.”
Because the researchers’ new NIR-II endoscopy system provides a generalizable design compatible with most current clinical endoscopies that are equipped with a standard coupling, they anticipate similar hardware upgrades will greatly promote the application of NIR-II fluorescence imaging in clinical settings.
† Suo, Yongkuan & Wu, Fengxia & Xu, Pengfei & Shi, Hui & Wang, Tingzhong & Liu, Hongguang & Cheng, Zhen. (2019). NIR‐II Fluorescence Endoscopy for Targeted Imaging of Colorectal Cancer. Advanced Healthcare Materials. 10.1002/adhm.201900974.