PyLoNApplication Notes

Acquiring and processing Raman spectral data for the C2-D stretching vibration of 2 deuterated histidine

We have recently reported the use of a deuterium label on the 2-carbon of histidine as a reporter of the protonation state of histidine, and possibly also as a reporter of histidine’s local environment. Implementation of this probe into proteins would provide an easy way to…Read Full Article

Tip-Enhanced Raman Scattering (TERS)

The ability to identify small quantities of adsorbed analyte or structural features down to the few-molecule level is a key challenge in nanotechnology. Optical spectroscopy provides an attractive means to achieve such identification via non-invasive implementations and the potential for chemical sensitivity. Raman scattering has emerged as a particularly powerful technique due to its…Read Full Article